A na-emepụta Pyrogens, nke a makwaara dị ka endotoxins, n'ime mgbidi extracellular nke nje bacteria Gram-negative, ya bụ, iberibe ozu nje.Ọ bụ ihe lipopolysaccharide nwere ihe jikọrọ ya na ihe dị ka puku kwuru puku ruo ọtụtụ narị puku, dabere na ụdị nje bacteria na-emepụta ya.N'ihe ngwọta nke mmiri na-ekpo ọkụ, oke molekụla ya nwere ike ịdịgasị iche site na narị puku kwuru puku ruo ọtụtụ nde
Ọ bụrụ na a gwakọtara ọnụ ọgụgụ pyrogen n'ime ọgwụ ahụ wee gbanye n'ime usoro ọbara mmadụ, ọ ga-ebute oke ahụ ọkụ na ọbụna ọnwụ.Ya mere, ọ dị ezigbo mkpa iji belata pyrogen dị n'ime mmiri ọgwụ dị ka o kwere mee, karịsịa mgbe injections (dị ka nnukwu infusion) dị ukwuu, ihe achọrọ nke pyrogen kwesịrị ịdị ike karị.
Depyrogenation nke mmiri mmiri injection (ma ọ bụ mmiri maka injection) bụ njikọ mmepụta ihe bụ isi na ụlọ ọrụ ọgwụ iji mee ka ọ mezuo ụkpụrụ ule nke Pharmacopoeia.Ka ọ dị ugbu a, a na-ewebata ụzọ maka depyrogenation n'ụdị 3 ndị a:
1. Usoro distillation na-emepụta mmiri depyrogenated, nke a na-eji dị ka mmiri maka injection, mmiri ịsacha, wdg, ma ọnụ ahịa ya dị elu.
2. Depyrogenation site na usoro mgbasa ozi.Otu n'ime ụzọ ndị ahụ bụ na elu adsorbent na-eme ka ihe ndị pyrogenic na-eme ka ihe ndị dị na ngwaahịa ahụ gafere.Ụzọ nke abụọ bụ na adsorbent na-eme ka ihe ngwaahịa ahụ na-eme ka pyrogen pụta.
3. Usoro nkewa nke membrane maka iwepụ pyrogen dị ka usoro ọhụrụ na nkà na ụzụ ọhụrụ na-ewu ewu ma tinye ya n'ọrụ na ụlọ ọrụ ọgwụ.Ụkpụrụ nke ultrafiltration iji wepụ pyrogen bụ iji akpụkpọ anụ ultrafiltration dị ntakịrị karịa ịdị arọ molekul nke pyrogen iji gbochie pyrogen.Enyerela usoro a akwụkwọ ikike.Ma nwee uru nke obere ọrụ ike, nnukwu mkpụrụ ngwaahịa na ezigbo ngwaahịa.
Oge nzipu: Eprel-20-2022